ParkinsonCanadaV1, Main, Exploration, bibRecord, 000690

Imaging pathological tau in atypical parkinsonian disorders

Identifieur interne : 000690 ( Main/Exploration ); précédent : 000689; suivant : 000691

Imaging pathological tau in atypical parkinsonian disorders

Auteurs : Sarah Coakeley [Canada] ; Antonio P. Strafella [Canada]

Source :

Current opinion in neurology [ 1350-7540 ] ; 2015.

RBID : PMC:4874783

English descriptors

KwdEn :
- Brain (diagnostic imaging), Brain (metabolism), Brain (pathology), Humans, Neuroimaging (methods), Parkinsonian Disorders (diagnostic imaging), Parkinsonian Disorders (metabolism), Parkinsonian Disorders (pathology), Radionuclide Imaging, tau Proteins (metabolism).
MESH :
- chemical , metabolism : tau Proteins.
- diagnostic imaging : Brain, Parkinsonian Disorders.
- metabolism : Brain, Parkinsonian Disorders.
- methods : Neuroimaging.
- pathology : Brain, Parkinsonian Disorders.
- Humans, Radionuclide Imaging.

Abstract

Purpose of review

This review examines the current literature on tau imaging in atypical parkinsonian disorders and other tauopathies.

Recent findings

There are a number of tau PET radiotracers that have demonstrated promising preliminary results in atypical parkinsonian disorders, such as progressive supranuclear palsy and corticobasal degeneration. These radiotracers were capable of selectively labeling tau in vitro and in vivo, with high affinity. Other radiotracers tested more extensively in patients with Alzheimer’s disease have also been able to successfully image tau deposition.

Summary

The development of tau radioligands for PET has led to the current testing of these tracers in clinical studies, many of which concentrate on patients with Alzheimer’s disease. Atypical parkinsonian disorders such as progressive supranuclear palsy and corticobasal degeneration are now being investigated as well. These disorders can be very difficult to diagnose, because of their clinical overlap with other parkinsonian disorders. Imaging tau using PET could serve as a diagnostic biomarker for these tauopathies and provide a means of assessing treatment that targets tau burden.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874783

DOI: 10.1097/WCO.0000000000000210
PubMed: 26110795
PubMed Central: 4874783

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose of review</title>
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<p id="P2">There are a number of tau PET radiotracers that have demonstrated promising preliminary results in atypical parkinsonian disorders, such as progressive supranuclear palsy and corticobasal degeneration. These radiotracers were capable of selectively labeling tau <italic>in vitro</italic>
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La maladie de Parkinson au Canada (serveur d'exploration)

Imaging pathological tau in atypical parkinsonian disorders

Imaging pathological tau in atypical parkinsonian disorders

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.